Who are the most unlikely screen couple?

@DukeLuke Steve Martin and the Brain in The Man With Two Brains. He falls in love with a brain in a jar. It doesn't get much odder than that. @dukemedia Professional cockney urchin Danny Dyer and one-time X-Files star and FHM's sexiest woman Gillian Anderson in ill-fated British revenge thriller Straightheads. @Hows , @filmcat , @Fantaxamus , @ontheroad2 9, @catburgler , @theythinkitsallover Ruth Gordon and Bud Cort in Harold and Maude. @carrion4891 Shia LaBeouf and Megan Fox in Transformers 1 and 2 – he'd never get her. @Victoriatheoldgoth Most French films pair an extraordinarily beautiful woman with an absolute gargoyle. @fishworld Nicole Kidman and Tom Cruise in Eyes Wide Shut. Has all the tension and compelling reality of a disposable in-flight magazine. Double points because they actually were a couple. @breakingranks Thora Birch and Steve Buscemi in Ghost World. @AnomieAndBonhomie Roger Moore and Grace Jones in A View To A Kill. She's huge, he's 57. @albert23 Dazzling film (and great dancing at his age) but Audrey Hepburn and Fred Astaire in Funny Face is a difficult one to believe. @54onthefloor Kip and Lafawnduh in Napoleon Dynamite. @Rence Sean Connery and Catherine Zeta Jones. @paddyboro Vincent Gallo and Christina Ricci in Buffalo 66. @rolandb Jeremy Irons and Juliette Binoche in Louis Malle's Damage showed a startling lack of chemistry. @nilpferd Possibly contentious, but I always found Grace Kelly's prim society dame and James Stewart's not-quite-convincing, hard-boiled slob of an action photographer completely mismatched in Rear Window. Though I think Hitchcock intended it that way. @LaTricoteuse Brando and Schneider in Last Tango in Paris. @daniellearwicker Rex Harrison and Elizabeth Taylor – first half of Cleopatra (and yet far more watchable than her and Burton in the second half, even though they were having an affair off screen). @reddog100 Angelina Jolie and Johnny Depp in The Tourist ... the trailer alone is enough to make one swear off fantasies involving gorgeous strangers! @DanAshcroft Hot-as-hell Sophia Myles with Jamie Bell in Hallam Foe (he plays a odd character who wears a dead badger on his head). @Milo2010 Jack Black and Kate Winslet in The Holiday. @EmmyS Roger Rabbit and Jessica Rabbit ... interspecies tomfoolery with a spangly red dress. @BadBoyBubby68 Am I bringing the tone down if I say Donkey and the dragon in Shrek? It just brings horrific graphic images to mind – and they breed! @Londontoffee Philip Seymour Hoffman and Marisa Tomei in Before the Devil Knows You're Dead. @piltrafilla Harry Dean Stanton and Nastassja Kinski in Paris, Texas. Although, that didn't ruin my enjoyment of it one jot. Beautiful film. @bruthead Ricky Gervais and Jennifer Garner in Invention of Lying. Never seen less screen chemistry. @charliekaufman Emma Thompson and Dustin Hoffman in Last Chance Harvey. Awful, awful. @Bowfinger Vin Diesel and anything made of flesh and bone. @Slabface Kirk Douglas and Farrah Fawcett in Saturn 3. Only couple as bad in movie history is Harvey Keitel and his really cheap-looking robot in the same woefully awful film. @NonOxbridgeColumnist John Cleese and Jamie Lee Curtis (A Fish Called Wanda). A tribute to both that they almost make it convincing.